Carbohydrate (N-Acetylglucosamine-6-O) Sulfotransferase 2 (CHST2) (Middle Region) Peptide
CHST2
Reactivity: Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN974972
Quick Overview for Carbohydrate (N-Acetylglucosamine-6-O) Sulfotransferase 2 (CHST2) (Middle Region) Peptide (ABIN974972)
Target
CHST2
(Carbohydrate (N-Acetylglucosamine-6-O) Sulfotransferase 2 (CHST2))
Origin
Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- VFQLYSPAGS GGRNLTTLGI FGAATNKVVC SSPLCPAYRK EVVGLVDDRV
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Chst2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CHST2 (Carbohydrate (N-Acetylglucosamine-6-O) Sulfotransferase 2 (CHST2))
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Background
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Chst2 catalyzes the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as L-selectin ligands. L-selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Chst2 participates in biosynthesis of L-selectin ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. It has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. It sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains.
Alias Symbols: AI428561, AW121776, C130041E03Rik, Chts2, GST-2, GlcNAc6ST, Gn6st
Protein Size: 530 -
Molecular Weight
- 58 kDa
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Gene ID
- 54371
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NCBI Accession
- NM_018763, NP_061233
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UniProt
- Q80WV3
Target
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